Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol
MoTrPAC Study Group, John M. Jakicic, Wendy M. Kohrt, Joseph A. Houmard, Michael E. Miller, Shlomit Radom‐Aizik, Blake B. Rasmussen, Éric Ravussin, Monica C. Serra, Cynthia L. Stowe, Scott Trappe, Hiba AbouAssi, Joshua Adkins, D. Lee Alekel, Euan A. Ashley, Marcas M. Bamman, Bryan C. Bergman, Daniel H. Bessesen, Nicholas T. Broskey, Thomas W. Buford, Charles Burant, Haiying Chen, Jeffrey W. Christle, Clary B. Clish, Paul M. Coen, David N. Collier, Katherine A. Collins, Dan M. Cooper, Tiffany Cortes, Gary Cutter, Gabriel S. Dubis, Facundo M. Fernández, Jonathon Firnhaber, Daniel E. Forman, David A. Gaul, Nicole R. Gay, Robert E. Gerszten, Bret H. Goodpaster, Marina A. Gritsenko, Fadia Haddad, Kim M. Huffman, Olga Ilkayeva, Catherine M. Jankowski, Christopher Jin, Neil M. Johannsen, Johanna L. Johnson, Leslie Kelly, Erin E. Kershaw, William E. Kraus, Maren R. Laughlin, Bridget Lester, Maléne E. Lindholm, Adam Lowe, Ching-Ju Lu, Joan McGowan, Edward L. Melanson, Stephen B. Montgomery, Samuel G. Moore, Kerrie L. Moreau, Michael J. Muehlbauer, Nicolas Musi, Venugopalan D. Nair, Christopher B. Newgard, Anne B. Newman, Barbara J. Nicklas, Bradley C. Nindle, Kelly E. Ormond, Paul Piehowski, Weijun Qian, Tuomo Rankinen, W. Jack Rejeski, Jeremy Robbins, Renee J. Rogers, Jessica L. Rooney, Scott Rushing, James Sanford, Irene E. Schauer, Robert S. Schwartz, Stuart C. Sealfon, Cris A. Slentz, Ruben C. Sloan, Kevin S. Smith, M Snyder, Jessica Spahn, Lauren M. Sparks, Maja Stefanović-Račić, Charles J. Tanner, Anna Thalacker‐Mercer, Russell P. Tracy, Todd A. Trappe, Elena Volpi, Martin J. Walsh, Matthew T. Wheeler, Leslie H. Willis
Abstract
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will be the first large trial to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. By generating a compendium of the molecular responses to exercise, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. Presented here is the design, protocols, and procedures for the MoTrPAC human studies.