Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease
Eduard Vilaplana, Elena Rodriguez‐Vieitez, Daniel Ferreira, Víctor Montal, Ove Almkvist, Anders Wall, Alberto Lleó, Eric Westman, Caroline Graff, Juan Fortea, Agneta Nordberg
Abstract
OBJECTIVE: C-DED)-PET, in familial autosomal-dominant Alzheimer disease (ADAD). METHODS: C-DED-PET. RESULTS: C-DED binding was negatively correlated with cortical MD and positively correlated with cortical thickness. CONCLUSIONS: Our proof-of-concept study is the first to show that microstructural and macrostructural changes can reflect underlying neuroinflammatory mechanisms in early stages of Alzheimer disease (AD). The findings support a role for neuroinflammation in AD pathogenesis, with potential implications for the correct interpretation of neuroimaging biomarkers as surrogate endpoints in clinical trials.