Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer
Wu-Xi Zhou, Chen Chen, Xiaoqin Liu, Ying Li, Yaolan Lin, Xiu-Tao Wu, Lingyi Kong, Jian‐Guang Luo
Topics & Concepts
ChemistryGlutaminolysisTriple-negative breast cancerGlutaminaseIC50Allosteric regulationPharmacologyDocking (animal)Cancer researchCancer cellApoptosisEnzymeCancerBreast cancerGlutamate receptorBiochemistryIn vitroReceptorGlycolysisInternal medicineBiologyNursingMedicineCancer, Hypoxia, and MetabolismCancer-related Molecular PathwaysMetabolomics and Mass Spectrometry Studies