Dynamic interactions of the 5-HT <sub>6</sub> receptor with protein partners control dendritic tree morphogenesis
Camille Pujol, Vincent Dupuy, Martial Sevéno, Léonie Runtz, Joël Bockaert, Philippe Marin, Séverine Chaumont‐Dubel
Abstract
R-GPRIN1 interaction enhanced agonist-independent, receptor-stimulated cAMP production without altering the agonist-dependent response in NG108-15 neuroblastoma cells. This interaction also promoted neurite extension and branching in NG108-15 cells and primary mouse striatal neurons through a cAMP-dependent protein kinase A (PKA)-dependent mechanism. This study highlights the complex allosteric modulation of GPCRs by protein partners and demonstrates how dynamic interactions between GPCRs and their protein partners can control the different steps of highly coordinated cellular processes, such as dendritic tree morphogenesis.
Topics & Concepts
MorphogenesisCell biologyNeurite5-HT receptorSerotoninReceptorBiologyBranching (polymer chemistry)ChemistryNeuroscienceBiochemistryOrganic chemistryIn vitroGeneReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research