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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants

Laurie B. Schenkel, Jennifer R. Molina, Kerren K. Swinger, Ryan Abo, Danielle J. Blackwell, Alvin Lu, Anne E. Cheung, W. David Church, Kaiko Kunii, Kristy Kuplast‐Barr, Christina R. Majer, Elena Minissale, Jan-Rung Mo, Mario Niepel, Christopher Reik, Yue Ren, Melissa M. Vasbinder, Tim J. Wigle, Victoria M. Richon, Heike Keilhack, Kevin W. Kuntz

2021Cell chemical biology78 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGene expressionMacrophageCell biologyImmune systemIn vivoIn vitroGenetic screenDownregulation and upregulationSignal transductionGenePhenotypeCancer researchBiochemistryImmunologyGeneticsPARP inhibition in cancer therapySignaling Pathways in DiseaseAutophagy in Disease and Therapy