A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
Laurie B. Schenkel, Jennifer R. Molina, Kerren K. Swinger, Ryan Abo, Danielle J. Blackwell, Alvin Lu, Anne E. Cheung, W. David Church, Kaiko Kunii, Kristy Kuplast‐Barr, Christina R. Majer, Elena Minissale, Jan-Rung Mo, Mario Niepel, Christopher Reik, Yue Ren, Melissa M. Vasbinder, Tim J. Wigle, Victoria M. Richon, Heike Keilhack, Kevin W. Kuntz
Topics & Concepts
BiologyGene expressionMacrophageCell biologyImmune systemIn vivoIn vitroGenetic screenDownregulation and upregulationSignal transductionGenePhenotypeCancer researchBiochemistryImmunologyGeneticsPARP inhibition in cancer therapySignaling Pathways in DiseaseAutophagy in Disease and Therapy