A PET-based fluorescent probe for monitoring labile Fe(<scp>ii</scp>) pools in macrophage activations and ferroptosis
Wanjin Xing, Hang Xu, Hang Xu, Huijuan Ma, Syed Ali Abbas Abedi, Shanshan Wang, Xingchen Zhang, Xiaogang Liu, Huan Xu, Huan Xu, Wei Wang, Kaiyan Lou
Abstract
a photo-induced photon transfer (PET) mechanism. The probe was applied for monitoring labile iron(II) changes in M1 and M2a macrophage activations and also erastin-induced ferroptosis, providing a powerful tool for selectively sensing LIP under both physiological and stressed conditions.
Topics & Concepts
FluorophoreFluorescenceChemistryQuenching (fluorescence)CoumarinPhotochemistryBiophysicsSelectivityCleavage (geology)Combinatorial chemistryBiochemistryCatalysisMaterials scienceOrganic chemistryBiologyPhysicsQuantum mechanicsComposite materialFracture (geology)Drug Transport and Resistance MechanismsTrace Elements in HealthIron Metabolism and Disorders