Modelling a ‘histidine brace’ motif in mononuclear copper monooxygenases
Arisa Fukatsu, Yuma Morimoto, Hideki Sugimoto, Shinobu Itoh
Abstract
A mononuclear copper complex bearing a 'histidine brace' is synthesised and characterised as an active-site model of mononuclear copper monooxygenases such as lytic polysaccharide monooxygenases (LPMOs) and particulate methane monooxygenase (pMMO). The complex has similar structural and functional features to the active sites of the enzymes.
Topics & Concepts
Methane monooxygenaseMonooxygenaseCopperChemistryLytic cycleBraceHistidineBiochemistryBiologyEnzymeImmunologyOrganic chemistryEngineeringMechanical engineeringCytochrome P450VirusMetal-Catalyzed Oxygenation MechanismsMicrobial bioremediation and biosurfactantsEnzyme Catalysis and Immobilization