Exploration of radiotherapy strategy for brain metastasis patients with driver gene positivity in lung cancer
Qian Bi, Xin Lian, Jing Shen, Fuquan Zhang, Tao Xu
Abstract
Targeted-first regimen was not found to improve patients' iPFS relative to radiotherapy-first regimen in patients with brain metastases. Radiotherapy-first regimen for brain metastases demonstrated superior local control compared to targeted-first regimen. Patient's age, radiotherapy modality, metastasis volume, number of metastases, extracranial disease status and therapy sequence may be related to local control of metastases.
Topics & Concepts
MedicineLung cancerRadiation therapyBrain metastasisRegimenClinical endpointInternal medicineOncologyCancerMetastasisClinical trialBrain Metastases and TreatmentLung Cancer Research StudiesLung Cancer Treatments and Mutations