EZH2: Its regulation and roles in immune disturbance of SLE
Yiying Yang, Ke Liu, Meidong Liu, Huali Zhang, Muyao Guo
Abstract
The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is currently found to participate in the pathogenesis of SLE through affecting multiple components of the immune system. This review mainly expounds the mechanisms underlying EZH2-mediated disruption of immune homeostasis in SLE patients, hoping to provide new ideas in the pathogenesis of SLE and new targets for future treatment.
Topics & Concepts
EZH2Immune systemPathogenesisEpigeneticsImmunologyBiologyMethylationHomeostasisCell biologyGeneticsGeneImmune Cell Function and InteractionEpigenetics and DNA MethylationAdenosine and Purinergic Signaling