Discovery of Pyrido[1,2-<i>a</i>]pyrimidine Mesoionic Compounds Containing Benzo[<i>b</i>]thiophene Moiety as Potential Pesticide Candidates
Desheng Zhang, Jian Zhang, Ting Liu, Shang Wu, Zengxue Wu, Sikai Wu, Runjiang Song, Baoan Song
Abstract
The increasing evolution of insect resistance has made it challenging for traditional insecticides to control the bean aphid (Aphis craccivora Koch). To address this pending issue, a range of pyrido[1,2-a]pyrimidine mesoionic compounds containing benzo[b]thiophene were designed and synthesized. The biological activity test results of the target compounds indicated that they had moderate to outstanding insecticidal activity against the bean aphid (Aphis craccivora) and moderate insecticidal activity against the white-backed planthopper (Sogatella furcifera). Compound L14 exhibited significant insecticidal activity against A. craccivora, with an LC50 value of 1.82 μg/mL, which was superior to triflumezopyrim (LC50 = 4.76 μg/mL). The results of enzyme activity assay showed that compound L14 had a definite inhibitory effect on ATPase. Moreover, the proteomics and docking findings of compound L14 suggested that it may act on the central nervous system of aphids and interact with nicotinic acetylcholine receptors. Therefore, compound L14 is a potentially novel insecticide candidate for further utilization.