Design, synthesis, and biological evaluation of novel N-Benzyl piperidine derivatives as potent HDAC/AChE inhibitors for Alzheimer’s disease
Pengxia Qin, Yingying Ran, Fei Xie, Yujing Liu, Chao Wei, Xiaoyi Luan, Jingde Wu
Topics & Concepts
ChemistryPiperidineChemical synthesisEnzyme inhibitorAcetylcholinesteraseAchéPharmacologyStereochemistryEnzymeIn vitroBiochemistryMedicineCholinesterase and Neurodegenerative DiseasesPhosphodiesterase function and regulationComputational Drug Discovery Methods