Continuous-Flow Synthesis of Δ<sup>9</sup>-Tetrahydrocannabinol and Δ<sup>8</sup>-Tetrahydrocannabinol from Cannabidiol
Benedetta Bassetti, Christopher A. Hone, C. Oliver Kappe
Abstract
High Resolution Image Download MS PowerPoint Slide A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuous-flow protocols for the preparation of (−)- trans -Δ 9 -tetrahydrocannabinol and (−)- trans -Δ 8 -tetrahydrocannabinol.
Topics & Concepts
CannabidiolTetrahydrocannabinolΔ9-tetrahydrocannabinolChemistryContinuous flowDronabinolIntramolecular forceStereochemistryCannabinoidCannabisBiochemistryPhysicsMedicineReceptorMechanicsPsychiatryInnovative Microfluidic and Catalytic Techniques InnovationCannabis and Cannabinoid ResearchAsymmetric Hydrogenation and Catalysis