Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation
Ning Yang, Zhiya Fan, Shiyang Sun, Xiaotong Hu, Yaqiu Mao, Changkai Jia, Xu Cai, Tingting Xu, Bingkun Li, Yi Li, Luobing Han, Ting Wei, Xiaohong Qian, Weijie Qin, Pengyun Li, Zhibing Zheng, Song Li
Topics & Concepts
ChemistryMutationCancer researchBiochemistryGeneBiologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis