Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines
Toka Omar, Pascal Ziltener, Erin Chamberlain, Zhenyu Cheng, Brent Johnston
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic and life-threatening infections in immunocompromised patients. A better understanding of the role that innate immunity plays in the control of P. aeruginosa infection is crucial for therapeutic development. Specifically, the role of unconventional immune cells like γδ T cells in the clearance of P. aeruginosa lung infection is not yet well characterized.
Topics & Concepts
Pseudomonas aeruginosaBiologyMicrobiologyLungProinflammatory cytokineLung infectionImmunologyInflammationPseudomonadalesCytokineBacteriaMedicineInternal medicineGeneticsImmune Cell Function and InteractionImmune Response and InflammationT-cell and B-cell Immunology