Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System
Christine Vazquez, Kellie A. Jurado
Abstract
The central nervous system (CNS) necessitates intricately coordinated immune responses to prevent neurological disease. However, the emergence of viruses capable of entering the CNS and infecting neurons threatens this delicate balance. Our CNS is protected from foreign invaders and excess solutes by a semipermeable barrier of endothelial cells called the blood-brain barrier. Thereby, viruses have implemented several strategies to bypass this protective layer and modulate immune responses within the CNS. In this review, we outline these immune regulatory mechanisms and provide perspectives on future questions in this rapidly expanding field.
Topics & Concepts
Immune systemCentral nervous systemRNABiologyNeuroscienceVirusImmune modulationVirologyModulation (music)RNA virusImmunologyGeneticsGenePhilosophyAestheticsinterferon and immune responsesViral Infections and Immunology ResearchImmune Cell Function and Interaction