Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2
Meng Xie, Mengyu Sun, Xiaoyu Ji, Dongxiao Li, Xiaoping Chen, Bixiang Zhang, Wenjie Huang, Tongyue Zhang, Yijun Wang, Dean Tian, Limin Xia
Abstract
These results demonstrated the tumorigenic and pro-metastatic role of BACH1 in HCC, which could be a promising biomarker for predicting poor prognosis and selecting patients who could benefit from combination therapy of IGF1R-targeted and PTK2-directed.
Topics & Concepts
Cancer researchInsulin-like growth factor 1 receptorMetastasisDownregulation and upregulationHepatocellular carcinomaBiologyImmunohistochemistryCancerGrowth factorMedicineInternal medicineReceptorImmunologyGeneBiochemistryUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism