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Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Seth J. Zost, Pavlo Gilchuk, Rita E. Chen, James Brett Case, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Elaine C. Chen, Elad Binshtein, Swathi Shrihari, Mario Ostrowski, Helen Y. Chu, Jonathan E. Didier, Keith W. MacRenaris, Taylor Jones, Samuel B. Day, Luke Myers, F. Eun‐Hyung Lee, Doan C. Nguyen, Igñacio Sanz, David R. Martinez, Paul W. Rothlauf, Louis-Marie Bloyet, Sean P. J. Whelan, Ralph S. Baric, Larissa B. Thackray, Michael Diamond, Robert H. Carnahan, James E. Crowe

2020Nature Medicine542 citationsDOIOpen Access PDF

Topics & Concepts

Monoclonal antibodyVirologyCoronavirusPandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AntibodyCoronavirus disease 2019 (COVID-19)Biology2019-20 coronavirus outbreakSpike ProteinImmunityProfiling (computer programming)ImmunologyDiseaseMedicineInfectious disease (medical specialty)OutbreakImmune systemComputer sciencePathologyOperating systemSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyAnimal Virus Infections Studies
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein | Litcius