Multiple aptamer recognition-based quantum dot lateral flow platform: ultrasensitive point-of-care testing of respiratory infectious diseases
Hengxuan Li, Xiaoyi Fu, Qimin You, Dawei Shi, Lingxuan Su, Minghui Song, Ruizi Peng, Ting Fu, Peng Wang, Weihong Tan
Abstract
towards the nucleocapsid protein and inactivated viruses, respectively, indicating that MARQ-LFIA improved detection sensitivity compared to reported methods. More critically, by testing thirty COVID-19 positive and twenty negative patient samples, the positive detection rate increased from 55.17% to 86.67% compared with commercially similar products. The universality of MARQ-LFIA was also investigated for diagnosing influenza B. We believe that MARQ-LFIA can be a promising POCT tool with potential applications in the areas of public health for the growing demand for precision diagnosis and treatment.
Topics & Concepts
AptamerQuantum dotPoint-of-care testingPoint of careRespiratory systemNanotechnologyPoint (geometry)Materials scienceMedicineImmunologyBiologyPathologyInternal medicineMathematicsGeneticsGeometryBiosensors and Analytical DetectionRespiratory viral infections researchAir Quality Monitoring and Forecasting