Nickel-Catalyzed Reductive Cross-Coupling of <i>N</i>-Acyl and <i>N</i>-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides
Erdong Qu, Shangzhang Li, Jin Bai, Yan Zheng, Wanfang Li
Abstract
Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.
Topics & Concepts
ChemistrySulfonylNitroCatalysisArylReductive eliminationAlkylNickelSubstrate (aquarium)Combinatorial chemistryCoupling reactionOrganic chemistryMedicinal chemistryGeologyOceanographyAdvanced Synthetic Organic ChemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis