Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation
Wen Zhang, Wenyue Wu, Ning Zhang, Congjun Li, Yameng Sun, Xiaodong Ge, Hui Han, Shuyan Chen, Anjian Xu, Sai Santosh Babu Komakula, Chao Wang, Nithyananthan Subramaniyam, Qi Han, Aiting Yang, Xuzhen Yan, Natalia Nieto, Hong You, Wei Chen
Abstract
: This study reveals the compensatory protective effects of HSC-derived MFAP-2 on liver fibrosis and its underlying mechanisms. Enhancing MFAP-2 in HSCs may therefore benefit patients with liver fibrosis.
Topics & Concepts
Hepatic stellate cellExtracellular matrixInflammationFibrosisLiver fibrosisCell biologyExtracellularChemistryPathologyMedicineBiologyImmunologyLiver Disease Diagnosis and TreatmentLiver physiology and pathologyEndoplasmic Reticulum Stress and Disease