SS-31 ameliorates hepatic injury in rats subjected to severe burns plus delayed resuscitation via inhibiting the mtDNA/STING pathway in Kupffer cells
Yin Wu, Chao Hao, Guangye Han, Xiongfei Liu, Changzheng Xu, Zhongtao Zou, Jinfeng Zhou, Jun Yin
Topics & Concepts
StingMitochondrionLiver injuryHepatocyteReactive oxygen speciesMitochondrial DNAPhenotypeOxidative stressCentrilobular necrosisBiologyCytosolCell biologyPharmacologyChemistryImmunologyGeneBiochemistryIn vitroEnzymeEngineeringAerospace engineeringinterferon and immune responsesImmune Response and InflammationInflammasome and immune disorders