Unmasking selective path integration deficits in Alzheimer’s disease risk carriers
Anne Bierbrauer, Lukas Kunz, Carlos Alexandre Gomes, Maike Luhmann, Lorena Deuker, Stephan Getzmann, Edmund Wascher, Patrick D. Gajewski, Jan G. Hengstler, Marina Fernandez-Alvarez, Mercedes Atienza, Davide Maria Cammisuli, Francesco Bonatti, Carlo Pruneti, Antonio Percesepe, Youssef Bellaali, Bernard Hanseeuw, Bryan A. Strange, José L. Cantero, Nikolai Axmacher
Abstract
ε4-carriers. Furthermore, posterior cingulate/retrosplenial cortex was involved in the recruitment of compensatory navigational strategies via supportive spatial cues. Our results provide evidence for selective PI deficits in AD risk carriers, decades before potential disease onset.
Topics & Concepts
Retrosplenial cortexEntorhinal cortexNeuroscienceDiseasePath integrationSpatial memoryPsychologyAnterior cingulate cortexApolipoprotein EAlzheimer's diseaseHippocampusMedicineWorking memoryCognitionPathologyMemory and Neural MechanismsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies