RNA N ⁶ ‐Methyladenosine Modifications and the Immune Response

Abstract

N 6 ‐methyladenosine (m 6 A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m 6 A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m 6 A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m 6 A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m 6 A modifications in the innate immune response, adaptive immune response, and viral infection.

Topics & Concepts