Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis
Lei Pang, Hongmei Liu, Hongyu Quan, Hehuan Sui, Yi Jia
Topics & Concepts
InflammasomeChemistryPyrin domainCaspase 1PharmacologyColitisIC50Inflammatory bowel diseaseBiochemistryIn vitroReceptorImmunologyDiseaseMedicineBiologyPathologyInflammasome and immune disorders