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Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis

Lei Pang, Hongmei Liu, Hongyu Quan, Hehuan Sui, Yi Jia

2022European Journal of Medicinal Chemistry32 citationsDOI

Topics & Concepts

InflammasomeChemistryPyrin domainCaspase 1PharmacologyColitisIC50Inflammatory bowel diseaseBiochemistryIn vitroReceptorImmunologyDiseaseMedicineBiologyPathologyInflammasome and immune disorders
Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis | Litcius