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Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer

Baijiao An, Yangyang Fan, Li Wei, Wenyan Nie, Haoran Nie, Mengxuan Wang, Jie Feng, Han Yao, Yin Zhang, Xingshu Li, Geng Tian, Geng Tian

2023Bioorganic Chemistry13 citationsDOI

Topics & Concepts

ChemistryCancer researchCell growthPhosphorylationProtein kinase BEGFR inhibitorsApoptosisMAPK/ERK pathwayCell cycle checkpointALK inhibitorCell cycleCellEpidermal growth factor receptorLung cancerCrizotinibReceptorBiochemistryBiologyInternal medicineMedicineMalignant pleural effusionLung Cancer Treatments and MutationsLung Cancer Research StudiesCancer therapeutics and mechanisms
Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer | Litcius