Copper-Catalyzed Chemoselective Coupling of <i>N</i>-Dithiophthalimides and Alkyl Halides: Synthesis of Unsymmetrical Disulfides and Sulfides
Bin Li, Bo-Xi Liu, Weidong Rao, Shusu Shen, Daopeng Sheng, Shun‐Yi Wang
Abstract
In this paper, we report an unprecedented copper-catalyzed disulfides or sulfides coupling reaction involving unactivated alkyl halides and N -dithiophthalimides. This reaction can be conducted under mild conditions using low-cost metal catalysts and exhibits high chemical selectivity and functional group compatibility, enabling the efficient assembly of various sulfides and disulfides.
Topics & Concepts
ChemistryHalideAlkylCatalysisSelectivityCopperCoupling reactionChemoselectivityCombinatorial chemistryMetalDisulfide bondFunctional groupReaction conditionsOrganic chemistryPolymerBiochemistrySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions