Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron
Takuya Hikima, Christian Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Abstract
-receptor-mediated currents are unaffected. Thus, somatodendritic DA release in the SNc autoinhibits the neuron that releases it.
Topics & Concepts
Substantia nigraAutoreceptorPars compactaDopamineNeuronInhibitory postsynaptic potentialChemistryNeuroscienceMidbrainNeurotoxinReceptorCell biologyBiologyBiochemistryDopaminergicCentral nervous systemAntagonistNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling