Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction
Elyse A. Watkins, Jennifer T. Antane, Jaeda Roberts, Kristen M. Lorentz, Sarah Zuerndorfer, Anya C. Dunaif, L.J. Bailey, Andrew C. Tremain, Mindy Nguyen, Roberto C. De Loera, Rachel P. Wallace, Rachel K. Weathered, Stephan Kontos, Jeffrey A. Hubbell
Abstract
dendritic cells. These results demonstrate that antigens associated with eryptotic erythrocytes induce lasting T cell dysfunction that could be protective in deactivating pathogenic T cells.
Topics & Concepts
Terminal (telecommunication)AntigenCell biologyImmunologyCellBiologyChemistryBiochemistryComputer scienceComputer networkImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses