Cardiac Tissue Engineering for the Treatment of Myocardial Infarction
Dongmin Yu, Xiaowei Wang, Lei Ye
Abstract
Poor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell engraftment and promote the therapeutic effects of the treatment for myocardial infarction. This mini-review summarizes the recent progress in cardiac tissue engineering of cardiovascular cells from differentiated human pluripotent stem cells (PSCs), highlights their therapeutic applications for the treatment of myocardial infarction, and discusses the present challenges of cardiac tissue engineering and possible future directions from a clinical perspective.
Topics & Concepts
Myocardial infarctionLimitingTissue engineeringMedicineInduced pluripotent stem cellCell therapyStem cellCardiologyTherapeutic approachIntensive care medicineInternal medicineBiomedical engineeringBiologyEngineeringCell biologyEmbryonic stem cellDiseaseGeneMechanical engineeringBiochemistryTissue Engineering and Regenerative MedicinePluripotent Stem Cells Research3D Printing in Biomedical Research