Unified Total Synthesis of Diverse Meroterpenoids from <i>Ganoderma Applanatum</i>
M. Šimek, Kateřina Bártová, Samy Issad, Miroslav Hájek, Ivana Cı́sařová, Ullrich Jahn
Abstract
A unified approach to meroterpenoids applanatumols B, V, W, X, and Y produced by the medicinal fungus Ganoderma applanatum and 2′-epi-spiroapplanatumine O is presented. The key synthetic sequence consists of a tandem anionic ketone allylation/oxy-Cope rearrangement/α-oxygenation furnishing an α-aminoxy ketone and a persistent radical effect-based 5-exo-trig cyclization leading to the trisubstituted cyclopentane core. The relative configuration of applanatumol V has to be revised. Some compounds display significant cytotoxic and antioxidant properties.
Topics & Concepts
CyclopentaneChemistryKetoneStereochemistryTotal synthesisTandemTerpeneOrganic chemistryComposite materialMaterials scienceFungal Biology and ApplicationsMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloids