Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti
Taylor K. Paisie, Melanie N. Cash, Massimiliano S. Tagliamonte, Afsar Ali, J. Glenn Morris, Marco Salemi, Carla Mavian
Abstract
Our phylodynamic analysis demonstrated that Vibrio cholerae Inaba strains in Haiti evolved directly from Ogawa strains. Our results support the hypothesis that after an initial Ogawa-dominated epidemic wave, V. cholerae Inaba was able to become the dominant strain thanks to a selective advantage driven by ongoing diversifying selection, independently from the mutational pattern in the wbeT gene.
Topics & Concepts
Vibrio choleraeBiologySerotypeEl TorMicrobiologyVirologyGeneticsBacteriaVibrio bacteria research studiesSalmonella and Campylobacter epidemiologyYersinia bacterium, plague, ectoparasites research