Modulation of <i>Lactobacillus rhamnosus</i> GG on the gut microbiota and metabolism in mice with <i>Clostridioides difficile</i> infection
Zhengjie Wu, Qiaomai Xu, Silan Gu, Qiangqiang Wang, Yunbo Chen, Longxian Lv, Beiwen Zheng, Kaicen Wang, Shuting Wang, Jiafeng Xia, Lanjuan Li
Abstract
and counteracting the side effects of vancomycin treatment. In both the preventive and therapeutic CDI mouse models, the oral LGG strain showed the ability to protect against primary and recurrent infections, indicating that probiotics have potential for treating intestinal diseases. Overall, these observations suggest that LGG can be applied as a preventive treatment for CDI or in combination with antibiotics to reduce recurrence.
Topics & Concepts
Lactobacillus rhamnosusClostridioidesAntibioticsVancomycinDiarrheaGut floraMedicineMicrobiologyLactobacillusImmunologyBiologyInternal medicineBacteriaStaphylococcus aureusGeneticsClostridium difficile and Clostridium perfringens researchGut microbiota and healthProbiotics and Fermented Foods