Subanesthetic isoflurane abates ROS-activated MAPK/NF-κB signaling to repress ischemia-induced microglia inflammation and brain injury
Zhiqiang Yao, Ningning Liu, Xiaoshan Zhu, Ling Wang, Yali Zhao, Qinqin Liu, Chunfang Gao, Juntang Li
Abstract
observation. These findings indicate that sub-anesthetic ISO post-conditioning abates the inflammation and apoptosis in OGD-stimulated rat microglia and the apoptosis of OGD-exposed neurons and the brain injuries of MCAO rats, suggesting it as a potentially effective therapeutic approach for ischemic brain damages.
Topics & Concepts
MicrogliaInflammationNF-κBMAPK/ERK pathwayIsofluraneSignal transductionApoptosisMedicinePharmacologyIschemiaCancer researchCell biologyChemistryImmunologyBiologyAnesthesiaInternal medicineBiochemistryAnesthesia and Neurotoxicity ResearchNeuroinflammation and Neurodegeneration MechanismsIntensive Care Unit Cognitive Disorders