A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer
Fang Wang, Xuejiao Yu, Jun Qian, Yumin Cao, Shunli Dong, Shenghua Zhan, Zhen Lü, Robert C. Bast, Qingxia Song, Youguo Chen, Yi Zhang, Jinhua Zhou
Topics & Concepts
Ovarian cancerPARP inhibitorCancer researchGene knockdownSynthetic lethalityDNA repairRAD51Cancer cellPoly ADP ribose polymeraseApoptosisCancerChemistryBiologyMedicineInternal medicineDNABiochemistryPolymerasePARP inhibition in cancer therapyProtein Degradation and InhibitorsDNA Repair Mechanisms