LncRNA and mRNA profiles of human milk-derived exosomes and their possible roles in protecting against necrotizing enterocolitis
Xiangyun Yan, Linjie Liu, Shuwen Yao, Yanjie Chen, Qinlei Yu, Chengyao Jiang, Wenjuan Chen, Xiaohui Chen, Shuping Han
Abstract
. We identified a total of 44 differentially expressed lncRNAs and 88 differentially expressed mRNAs between Term-Exos and Pre-Exos. Further GO and KEGG pathway analysis showed that the lncRNA-mRNA network of HM-Exos was associated with the JAK-STAT signaling pathway, bile secretion and the AMPK signaling pathway, which are predicted to be involved in the proliferation of cells. Therefore, this study reveals for the first time the important roles of human milk derived lncRNAs and mRNAs in protecting against necrotizing enterocolitis. These results provide new insight into the development of NEC.
Topics & Concepts
Necrotizing enterocolitisMicrovesiclesExosomeBiologyWnt signaling pathwayMessenger RNASignal transductionmicroRNACancer researchMedicineImmunologyCell biologyInternal medicineGeneGeneticsInfant Nutrition and HealthCongenital Anomalies and Fetal SurgeryExtracellular vesicles in disease