Stereoselective migratory heteroaryltrifluoromethylation of allylic amines <i>via</i> electrosynthesis
Jianyong Lan, Kejun Lin, Xing Zhang, Tingshun Zhu
Abstract
With key steps involving electro-oxidation-triggered Smiles-type radical rearrangement and chemical reduction with SO 2 , a formal redox-neutral electrosynthesis for migratory heteroaryltrifluoromethylation of allylic amines was developed.
Topics & Concepts
ElectrosynthesisAllylic rearrangementStereoselectivityChemistryOrganic chemistryCombinatorial chemistryStereochemistryCatalysisElectrochemistryPhysical chemistryElectrodeFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques