Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis
Weiguo Li, Yasir Abdul, Raghavendar Chandran, Sarah Jamil, Rebecca Ward, Mohammed Abdelsaid, Guangkuo Dong, Susan C. Fagan, Adviye Ergul
Abstract
The current study shows for the first time that diabetes does not promote aberrant cerebrovascularization in female rats. This contrasts with what we reported in male animals in various diabetes models. Deferoxamine preserved recognition memory function in diabetic female animals after stroke. The effect(s) of stroke and deferoxamine on cerebrovascular density and microglial activation also appear(s) to be different in female diabetic rats. Lastly, deferoxamine exerts detrimental effects on animals and BMVECs under control conditions.
Topics & Concepts
DeferoxamineDiabetes mellitusStroke (engine)MedicineNeuroscienceInternal medicineEndocrinologyPsychologyEngineeringMechanical engineeringEpigenetics and DNA MethylationCancer-related molecular mechanisms researchNeuroinflammation and Neurodegeneration Mechanisms