Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models
Saurabh Upadhyay, Valerij Talagayev, Sung‐Woo Cho, Gerhard Wolber, Moustafa T. Gabr
Topics & Concepts
DruggabilityProinflammatory cytokineChemistryImmune checkpointImmune systemT cellCancer researchCD28Small moleculeVirtual screeningCancerDrug discoveryCancer immunotherapyImmunotherapyBiological activityBiologyPharmacologyBlockadePhenotypic screeningCancer cellDrug resistanceComputational biologyCellIn vitroCell cultureMultiple drug resistanceT-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses