Construction of bifunctional electrochemical biosensors for the sensitive detection of the SARS-CoV-2 N-gene based on porphyrin porous organic polymers
Jing Cui, Lun Kan, Fang Cheng, Jiameng Liu, Linghao He, Yulin Xue, Shaoming Fang, Zhihong Zhang
Abstract
of N-gene. The sensing performances of both the TAPP-DPDD-POP-based aptasensor and immunosensor were better than those of existing electrochemical biosensors for analyzing the N-gene, accompanied with excellent stability, high selectivity and reproducibility. The TAPP-DPDD-POP-based aptasensor and immunosensor were then employed to detect the N-gene from various environments, including human serum, river water, and seafoods. This work provides a new method of using an electrochemically active POP to sensitively and selectively analyze SARS-CoV-2 in diverse environments.
Topics & Concepts
PorphyrinDetection limitBifunctionalStackingBiosensorCombinatorial chemistryChemistryElectrochemistrySelectivityPolymerChromatographyMaterials scienceOrganic chemistryBiochemistryElectrodeCatalysisPhysical chemistryAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testingLuminescence and Fluorescent Materials