Arylation and Alkyne Insertion to C-Acylimines: Rapid Access to 2-Trifluoromethylated and Other Fully Substituted Pyrroles in One Pot
Srinivasarao Yaragorla, Arun Doma, Rajeshwari Tangellapally
Abstract
Abstract A one-pot, four-component strategy for the synthesis of trifluoromethylated, and other fully-substituted pyrroles is reported using minimum loading of calcium catalyst at room temperature. A variety of arenes, α-keto aldehydes, amines, and activated alkynes took part in the reaction to produce high-yielding products. Friedel–Crafts arylation and aza-Michael addition are the key reactions in this approach.
Topics & Concepts
ChemistryAlkyneCatalysisFriedel–Crafts reactionOrganic chemistryCombinatorial chemistryFluorine in Organic ChemistrySynthesis and Characterization of PyrrolesCatalytic C–H Functionalization Methods