Metabolites from Clonostachys Fungi and Their Biological Activities
Peipei Han, Xuping Zhang, Dan Xu, Bowen Zhang, Daowan Lai, Ligang Zhou
Abstract
Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.
Topics & Concepts
BiologySecondary metabolismAntimicrobialHypocrealesAgrochemicalSecondary metaboliteTerpenoidPlant use of endophytic fungi in defenseBotanyAscomycotaMicrobiologyBiochemistryEcologyAgricultureBiosynthesisGeneEnzymePlant Pathogens and Fungal DiseasesTraditional and Medicinal Uses of AnnonaceaePhytochemical compounds biological activities