Antimycobacterial Rufomycin Analogues from <i>Streptomyces atratus</i> Strain MJM3502
Bin Zhou, Gauri Shetye, Yu Yang, Bernard D. Santarsiero, Larry L. Klein, Cele Abad‐Zapatero, Nina M. Wolf, Jinhua Cheng, Ying‐Yu Jin, Hanki Lee, Joo‐Won Suh, Hyun Lee, Jonathan Bisson, James B. McAlpine, Shao‐Nong Chen, Sang‐Hyun Cho, Scott G. Franzblau, Guido F. Pauli
Abstract
, paired with favorable selectivity (selectivity index >60), which collectively underscores the promise of the rufomycins as potential anti-TB drug leads.
Topics & Concepts
AntimycobacterialStreptomycesSelectivityStrain (injury)StereochemistryMicrobiologyChemistryBiological activityBiologyMycobacterium tuberculosisTuberculosisBiochemistryCombinatorial chemistryBacteriaIn vitroMedicineGeneticsPathologyAnatomyCatalysisAntibiotic Resistance in BacteriaTuberculosis Research and EpidemiologyMicrobial Natural Products and Biosynthesis