Peptide late-stage C(sp<sup>3</sup>)–H arylation by native asparagine assistance without exogenous directing groups
Yiyi Weng, Xingxing Ding, João C. A. Oliveira, Xiaobin Xu, Nikolaos Kaplaneris, Meijie Zhu, Hantao Chen, Zhuo Chen, Lutz Ackermann
Abstract
)-H bonds at the N-terminus of di-, tri-, and tetrapeptides have been achieved. Likewise, we have constructed a key building block for accessing agouti-related protein (AGRP) active loop analogues in a concise manner.
Topics & Concepts
AsparaginePeptideChemistryStage (stratigraphy)StereochemistryCombinatorial chemistryMedicinal chemistryBiochemistryBiologyAmino acidPaleontologyCatalytic C–H Functionalization MethodsClick Chemistry and ApplicationsSynthesis and Catalytic Reactions