Emergence of New Non–Clonal Group 258 High-Risk Clones among <i>Klebsiella pneumoniae</i> Carbapenemase–Producing <i>K. pneumoniae</i> Isolates, France

Abstract

I n Klebsiella pneumoniae bacteria, resistance to car- bapenems results in 2 main mechanisms: the production of an extended spectrum -lactamase or plasmid-borne cephalosporinase associated with a decrease in permeability of the outer membrane (especially through alteration of OmpK35 and OmpK36 porins), or the production of a carbapenemase (1,2). In France, these carbapenemases are Ambler's class A KPC enzymes; class B metallo--lactamases of NDM-, VIM-and, to a lesser extent, IMP-type; and Ambler's class D oxacillinases of OXA-48-like type (3,4).

Topics & Concepts