Photo‐Induced Ruthenium‐Catalyzed C−H Benzylations and Allylations at Room Temperature
Julia Struwe, Korkit Korvorapun, Agnese Zangarelli, Lutz Ackermann
Abstract
The ruthenium-catalyzed synthesis of diarylmethane compounds was realized under exceedingly mild photoredox conditions without the use of exogenous photocatalysts. The versatility and robustness of the ruthenium-catalyzed C-H benzylation was reflected by an ample scope, including multifold C-H functionalizations, as well as transformable pyrazoles, imidates and sensitive nucleosides. Mechanistic studies were indicative of a photoactive cyclometalated ruthenium complex, which also enabled versatile C-H allylations.
Topics & Concepts
RutheniumCatalysisCombinatorial chemistryChemistryScope (computer science)Photoredox catalysisRobustness (evolution)PhotochemistryOrganic chemistryComputer sciencePhotocatalysisBiochemistryProgramming languageGeneCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions