A Phase 1 First-in-Human Study of Abbv-383, a BCMA × CD3 Bispecific T-Cell-Redirecting Antibody, As Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma
Peter M. Voorhees, Anita D’Souza, Katja Weisel, David D. Hurd, Raphael Teipel, Alfred Chung, Cesar Rodriguez, Sascha A. Tuchman, Neha Korde, Hana Safah, Orlando F. Bueno, Neil R. Pumford, Tanya S Rosenberg, Rajvineeth Kumar Pothacamury, Jeremy A. Ross, Akshanth R. Polepally, Shane Lee, Ziyi Jin, Chetasi Talati, Ravi Vij, Shaji Kumar
Topics & Concepts
MedicineBispecific antibodyMultiple myelomaRefractory (planetary science)DaratumumabPhases of clinical researchAntibodyOncologyInternal medicineCancer researchBortezomibImmunologyClinical trialMonoclonal antibodyPhysicsAstrobiologyMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchSynthesis and Biological Evaluation