Silver-Catalyzed C–H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes
Xiaolei Zhu, Yangen Huang, Xiu‐Hua Xu, Feng‐Ling Qing
Abstract
The oxidative C–H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reactions are promoted by the combination of catalytic AgNO3 and Selectfluor or K2S2O8 to give ArOCF2- and ArSCF2-substituted heteroaromatic compounds in moderate to high yields.
Topics & Concepts
SelectfluorChemistryCatalysisDecarboxylationOxidative decarboxylationCombinatorial chemistryOxidative phosphorylationMedicinal chemistryOrganic chemistryBiochemistryFluorine in Organic ChemistryInorganic Fluorides and Related Compounds