Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer
Vaibhav Jain, Ravi K. Amaravadi
Abstract
SUMMARY: Autophagy is an adaptive response to metabolic and therapeutic stress, especially in treatment-refractory cancers such as pancreatic cancer. In this issue of Cancer Discovery, two groups establish ferritinophagy, a selective autophagy program that could become a drug target, as the mechanism that pumps iron into mitochondria via the lysosome, enabling survival and therapy resistance in pancreas cancer. See related article by Santana-Codina et al., p. 2180 (3). See related article by Ravichandran et al., p. 2198 (4).
Topics & Concepts
AutophagyPancreatic cancerCancerLysosomeRefractory (planetary science)Drug resistancePancreasCancer researchCancer therapyMedicineOncologyBiologyInternal medicineBiochemistryApoptosisEnzymeMicrobiologyAstrobiologyAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseHIV Research and Treatment