Stimuli-responsive fluorescent nanogel: a nonconventional donor for ratiometric temperature and pH sensing
Soumen Ghosh, Mohd Avais, Subrata Chattopadhyay
Abstract
an aza-Michael polyaddition reaction in water. In the next stage, doxorubicin (a FRET acceptor) is covalently linked with the nanogel (NANO-PAMAM, a nonconventional FRET donor) to form a ratiometric nanosensor for temperature and pH sensing. MTT assay revealed comparable biocompatibility of the donor nanogels (NANO-PAMAM) and nanosensors (NANO-PAMAM-DOX).
Topics & Concepts
NanogelNanosensorFörster resonance energy transferFluorescenceChemistryBiocompatibilityNano-Covalent bondNanotechnologyPhotochemistryBiophysicsMaterials scienceDrug deliveryOrganic chemistryBiologyComposite materialPhysicsQuantum mechanicsNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers