A multiscale free energy method reveals an unprecedented photoactivation of a bimetallic Os(<scp>ii</scp>)–Pt(<scp>ii</scp>) dual anticancer agent
Marta E. Alberto, Antonio Francés‐Monerris
Abstract
MMCT) character with no precedents in the scarce Ru(II)-Pt(II) analogues, indicative of a large synergistic effect between the Os(II) and Pt(II) metals and crucial in the photolabilization process of the Pt(II)-Cl bond. This is the first evidence of the ability of Os(II) to promote photoactivation of the Pt(II)-moiety, a contingency that would open new perspectives in this emerging field. The designed complex is therefore able to combine the traditional activity in photodynamic therapy (PDT) with the photoactivated chemotherapy (PCT) exerted by the Pt(II) unit, representing a new paradigm for a combined PDT/PCT anticancer approach while providing an advance in the methodology used to describe the photochemistry of transition-metal complexes in solution.